Glutathione or GSH is the most important and powerful intracellular anti-oxidant that the body makes!What is glutathione? Glutathione is a tripeptide molecule made inside cells from the amino acids L-glutamine, L-cysteine and L-glycine. The sulfur atom in L-cysteine is what binds heavy metals and toxins and aids in their removal from the body. Glutathione is also very crucial for proper mitochondrial function and energy production. Glutathione is also needed to protect DNA from damage. Many individuals with chronic illness (chronic infections (i.e. herpes, HIV, Lyme's disease), chronic fatigue, fibromyalgia, heavy metal toxicity, candida overgrowth, etc.) have very low levels of glutathione in their tissues. Heavy metals (i.e. mercury, lead, cadmium) not only cause the body's tissues to use up their supply of glutathione, but they also "directly" inhibit the production of more glutathione by displacing magnesium from the enzyme that makes glutathione! Also, as we get older, our bodies ability to make glutathione declines.
So why not just supplement glutathione to boost the body's levels of glutathione and help restore better health. This has been tried, but once glutathione reaches the stomach it is rapidly degraded and is of no use. Some people have supplemented pre-cursors to glutathione i.e. N-acetyl-cysteine (called NAC for short) to provide the body with the most crucial amino acid needed to make glutathione. But remember some individuals are not able to synthesize glutathione very well due to heavy metal toxicity and/or magnesium deficiencies. Also, NAC is very smelly due to the sulfur atom. If you pass gas while taking NAC, please be prepared to warn others of the horrible smell that is coming their way (i.e. rotten eggs)! Some doctors administer glutathione intravenously. This method works, but obviously it involves a lot of expense given the office visit and the cost of the I.V.
Well thanks to the development of a new form of glutathione called S-Acetyl-Glutathione, there a now a way to supplement glutathione orally without the nasty taste or smell of the pre-cursor NAC or the expense of I.V. glutathione. S-Acetyl-Glutathione is the first orally stable form of glutathione that is absorbed intact and increases intracellular glutathione levels. The acetyl group is attached to the sulfur atom of cysteine in the glutathione molecule. Placing the acetyl group on the sulfur atom of cysteine both protects it from oxidation in the digestive tract and reduces the nasty smell and taste of the sulfur atom. There is NO smelly gas when you take S-Acetyl-Glutathione.
S-Acetyl-Glutathione is a lipid-like molecule that is taken up intact by chylomicrons in the digestive tract. Once S-Acetyl-Glutathione reaches the blood stream, the acetyl group protects it from breakdown by peptidases. Studies show that S-Acetyl-Glutathione crosses the cell membrane more easily than glutathione itself. Once inside the cell, the acetyl group on S-Acetyl-Glutathione is removed and the glutathione molecule is free inside the cell which is exactly where it is needed!!
Did you know that glutathione is not only important for detoxification and energy production, but it is also crucial for proper functioning of the immune system? Too little glutathione in the body results in chronic inflammation because glutathione is needed for the balance between cell-mediated immunity (the TH1 pathway) and humoral immunity (the TH2 pathway or antibodies). T-lymphocytes direct the 2 sides of the immune system. When there too little glutathione present in the body, the humoral side of the immune system dominates and results in the production of cytokines and antibodies that produce a great deal of tissue inflammation. Supplementing S-Acetyl-Glutathione helps restore the balance to the immune system and relieves this chronic inflammatory cycle. If you suffer from chronic pain and inflammation, a chronic infection, or chronic fatigue, then you need to give S-Acetyl-Glutathione a try!
Illnesses that have responded well to S-Acetyl-Glutathione supplementation are Hepatitis, Herpes, Shingles, HIV/AIDS, Lyme's Disease, Cancer, Multiple Sclerosis, Parkinson's Disease, Autism, Allergies, Asthma, Chronic Fatigue Syndrome and Fibromylagia.
We offer FREE shipping on S-Acetyl-Glutathione for customers in the USA. Pricing is $74.95 per bottle of 60 capsules, 300 mg each. The recommended dose is 1 capsule in the morning and 1 capsule in the evening. We also now have a 100 mg version for $34.95 per bottle of 60 capsules and a 200 mg version for $54.95 per bottle of 60 capsules.
Ingredients: Each capsule contains S-Acetyl Glutathione (300 milligrams) and microcrystalline cellulose. 60 capsules per bottle.
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SCIENTIFIC REFERENCES on S-Acetyl-Glutathione
1. Witschi A, Reddy S, Stofer B, Lauterburg BH. The systemic availability of oral glutathione. Eur J Clin Pharmacol. 1992;43(6):667-9. PMID: 1362956
2. Hagen TM, Wierzbicka GT, Sillau AH, Bowman BB, Jones DP. Bioavailability of dietary glutathione: effect on plasma concentration. Am J Physiol. 1990 Oct;259(4 Pt 1):G524-9. PMID: 2221062
3. Cacciatore I, Cornacchia C, Mollica A, Pinnen F, Di Stefano A. Prodrug Approach for Increasing Cellular Glutathione Levels. Molecule. 3 March 2010. PMID: 20335977
4. Vogel JU, Cinatl J, Dauletbaev N, Buxbaum S, Treusch G, Cinatl J Jr, Gerein V, Doerr HW. Effects of S-acetylglutathione in cell and animal model of herpes simplex virus type 1 infection. Med Microbiol Immunol. 2005 Jan;194(1-2):55-9. PMID: 14624358
5. Locigno R, Pincemail J, Henno A, Treusch G, Castronovo V. S-acetyl-glutathione selectively induces apoptosis in human lymphoma cells through a GSH-independent mechanism Int J Oncol. 2002 Jan;20(1):69-75. PMID: 11743644
6. Fraternale A, Paoletti MF, Casabianca A, Orlandi C, Schiavano GF, Chiarantini L, Clayette P, Oiry J, Vogel JU, Cinatl J Jr, Magnani M. Inhibition of murine AIDS by pro-glutathione (GSH) molecules. Antiviral Res. 2008 Feb;77(2):120-7. PMID: 18164447
7. Locigno R, Pincemail J, Henno A, et al. S-Acetyl-glutathione selectively induces apoptosis in human lymphoma cells through a GSH-independent mechanism. Int J Oncol. 2002 Jan;20(1):69-75. PMID: 11743644
8. Lomaestro BM, Malone M. Glutathione in health and disease: pharmacotherapeutic issues. Ann Pharmacother. 1995 Dec;29(12):1263-73. PMID: 8672832
9. Vogel J, Cinatl J, Dauletbaev N, et al. Effects of S-acetylglutathione in cell and animal model of herpes simplex virus type 1 infection. Med Microbiol Immunol. 2005 Jan;194(1-2):55-59. PMID: 14624358
10. Ballatori N, Krance SM, Notenboom S, et al. Glutathione dysregulation and the etiology and progression of human diseases. Biol Chem. 2009 Mar;390(3):191-214. PMID: 19166318
11. Richman PG, Meister A. Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione. J Biol Chem. 1975 Feb 25;250(4):1422-26. PMID: 1112810
12. Anderson ME, Powrie F, Puri RN, et al. Glutathione monoethyl ester: preparation, uptake by tissues, and conversion to glutathione. Arch Biochem Biophys. 1985 Jun;239(2):538-48. PMID: 4004275
13. Anderson ME, Nilsson M, Sims NR. Glutathione monoethyl ester prevents mitochondrial glutathione depletion during focal cerebral ischemia. Neurochem Int. 2004 Feb;44(3):153-59. PMID: 14568558
14. Kretzschmar M. Regulation of hepatic glutathione metabolism and its role in hepatotoxicity. Exp Toxicol Pathol. 1996 Jul;48(5):439-46. PMID: 8765689
15. Fraternale A, Paoletti MF, Casabianca A, et al. Antiviral and immunomodulatory properties of new pro-glutathione (GSH) molecules. Curr Med Chem. 2006;13(15):1749-55. PMID: 16787218
16. Kretzschmar M, Klinger W. The hepatic glutathione system—influences of xenobiotics. Exp Pathol. 1990;38(3):145-64. PMID: 2192911
17. Donnerstag B, Ohlenschlager G, Cinatl J, et al. Reduced glutathione and S-acetylglutathione as selective apoptosis-inducing agents in cancer therapy. Cancer Lett. 1996 Dec;110(1-2):63-70. PMID: 9018082
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